脓毒症患者血清G蛋白偶联雌激素受体-1水平及其与死亡的关系：一项前瞻性研究 

贵州医科大学   麻醉与心脏电生理课题组

翻译 : 李奕  

编辑 : 严旭  

审校 : 曹莹

背景：性激素雌激素在创伤和脓毒症中具有免疫支持作用，与其免疫调节作用有关。本研究的目的是检测（血清G蛋白偶联雌激素受体-1）GPER-1在脓毒症和脓毒症相关死亡率中的预后作用。

方法：对总共160名因败血症在重症监护室随访的患者的数据进行了前瞻性评估。将患者分为两组，即幸存者组和非幸存者组。计算每个患者的顺序器官衰竭评估（SOFA）评分、APACHE II评分和charlson共病指数（CCI）。评估每个患者的血清DPER-1水平。

结果：与未存活患者相比，存活患者的PLT、CRP、GPER-1、SOFA和APACHE II评分水平显著升高。GPER-1水平与CRP水平、SOFA和APACHE II评分呈显著正相关。ROC曲线分析显示，GPER-1预测28天死亡率的敏感性为85.7%，特异性为72.1%。GPER-1和APACHE II评分被确定为预测死亡率的独立预后因素。

结论：血清GPER-1可作为败血症患者生存的新的预后因素。

原始文献来源 ： 

Hüseyin A Findikli , Murat Erdoğan , et al. Serum G protein-coupled estrogen receptor-1 levels and its relation with death in patients with sepsis: a prospective study.[J].Minerva Anestesiol. 2021 May;87(5):549-555.

英文原文

Serum G protein-coupled estrogen receptor-1 levels and its relation with death in patients with sepsis: a prospective study

Abstract

Background:The sex hormone estrogen has an immune-supporting role in both trauma and sepsis-related to its immune-modulator role. The aim of the current study was to examine the prognostic role of (serum G Protein-coupled estrogen receptor-1) GPER-1 in sepsis and sepsis-related mortality.

Method:Prospective evaluation was made of the data on a total 160 patients followed-up in the Intensive Care Unit because of sepsis. Patients were separated into two groups as survivor and non-survivor group. The Sequential Organ Failure Assessment (SOFA) Score, APACHE II Score and Charlson Comorbidity Index (CCI) were calculated for each patient. Serum GPER-1 levels were evaluated for each patient.

Results:Compared with non-survivors, the surviving patients were determined with significantly higher levels of PLT, CRP, GPER-1, SOFA, and APACHE II scores. The GPER-1 levels showed a significant positive correlation with CRP levels, SOFA, and APACHE II scores. ROC curve analysis demonstrated 85.7% sensitivity and 72.1% specificity of GPER-1 to predict 28-day mortality. GPER-1 and APACHE II scores were determined to be an independent prognostic factor for predicting mortality.

Conclusion: Serum GPER-1 can be used as a new prognostic factor for survival in patients diagnosed with sepsis.

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来源 | 健康界

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